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Very long chain (C22C24) ceramides are synthesized by ceramide synthase 2 (CerS2) and a CerS2 null mouse displays hepatopathy because of depletion of C22C24 ceramides, elevation of C16-ceramide and/or elevation of sphinganine [89]

Alterations in sperm DNA, caused by environmental exposure, are linked to both recurrent pregnancy losses and adverse health outcomes in children, including behavioral and physical disorders [155,156]

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Gut 66 , 168179 (2017)